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With this method, a number of bifunctional products were being well prepared in fantastic to fantastic yields. Equally of these two examples concerned pricey rhodium catalyst. To address this difficulty, they [27] explored a synergistic cobalt and copper catalytic process utilizing a similar approach to offer 1H-indazoles 35 (Plan twelve). With thi

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Even further, the terminal phenyl moiety of 97g participated in π–π interaction with Phe699. This was also noticed from the docking study of 97r. Also, the oxygen in the tricyclic ring of 97r was observed to kind a hydrogen bond with Met769, whereas the nitrogen of your quinoxaline team participated in hydrogen bonding with Asp831 and lys721.Cl

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